> -----------
> #IfWinActive ZTreeW64 v
> F11::
> Run Notepad
> ; Do other stuff if needed
> return
> F12::
> Run Calc
> ; Do other stuff if needed
> return
> #IfWinActive
> -----------

I use AutoHotkey to redefine tons of keys, but never
reassign naked F11 or F12. I always use a combo with
WinKey and other modifiers.

However, Microsoft keeps stealing my WinKey mappings by adding
new features. I don't mind, I like that lots of Windows
functions are now accessibly via hotkeys, but one has to
force oneself to learn new things. It's worth it.